Research
Escape: Adhesion, Survival
Tumor clusters escape the gland in stage T3a cancer. The image to the right shows a histological section of a PCa cluster within a vessel, which also requires penetrating the smooth muscle surrounding the vessel.
Cell adhesion mediated drug resistance (CAM-DR) reveals how tumor cells change to withstand hydroxyl radical damage and shear forces. We hypothesize that disrupting lineage-specific cell adhesion in aggressive cancers will make escaping clusters more vulnerable to innate immunity.
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Paxson AI, Chang LH, Gard JMC, Harryman WL, Nelson CS, Salmon SB, Marr KD, Wachsmuth LM, Ramanathan A, Ran J, Kapoor A, Marugan JJ, Henderson MJ, Sanchez TW, Cress AE. Phenotype plasticity and altered sensitivity to chemotherapeutic agents in aggressive prostate cancer cells. Front Cell Dev Biol. 2023 Nov 16;11:1285372. doi: 10.3389/fcell.2023.1285372. PMID: 38046670; PMCID: PMC10690371.
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Harryman WL, Hinton JP, Rubenstein CP, Singh P, Nagle RB, Parker SJ, Knudsen BS, Cress AE. The Cohesive Metastasis Phenotype in Human Prostate Cancer. Biochim Biophys Acta. 2016 Dec;1866(2):221-231. doi: 10.1016/j.bbcan.2016.09.005. Epub 2016 Sep 24. PMID: 27678419; PMCID: PMC5534328.
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Harryman WL, Pond E, Singh P, Little AS, Eschbacher JM, Nagle RB, Cress AE. Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. Am J Transl Res. 2016 Feb 15;8(2):940-54. PMID: 27158381; PMCID: PMC4846938.
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Samulitis BK, Pond KW, Pond E, Cress AE, Patel H, Wisner L, Patel C, Dorr RT, Landowski TH. Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors. Cancer Biol Ther. 2015;16(1):43-51. doi: 10.4161/15384047.2014.986967. PMID: 25485960; PMCID: PMC4623403.
